Aquatic animal tumor model

Aquatic animal tumor models are an important tool for cancer research, helping to understand tumor biology, drug efficacy, and disease progression.

Aquatic Animals as Tumor Models

Aquatic animal tumor models use marine species' unique physiological and genetic characteristics to study tumor occurrence and development. They also present ethical advantages over mammalian models, allowing in vivo studies with reduced regulatory burdens. In addition, these models enable researchers to conduct longitudinal studies of cancer evolution and therapy response, leading to a deeper understanding of tumor heterogeneity.

SpeciesAdvantagesApplications
Zebrafish (Danio rerio)
  • It is one of the most prominent models.
  • It has transparent embryos.
  • Rapid development and high genetic similarity to humans.
  • Tumor growth and metastasis can be observed in real time.
  • Zebrafish can be genetically manipulated to develop specific cancer types to gain insight into the molecular pathways of tumorigenesis.
  • A powerful platform for high-throughput screening of anticancer compounds.
Medaka (Oryzias latipes)
  • At least 15 inbred strains have already been described.
  • Using inbred strains to trace the transplanted cells in vivo in adults without immunosuppression.
  • To explore the effects of environmental pollutants on cancer development.
  • Revealed how external factors affect tumor formation.

Preclinical Validation

Evaluate the efficacy of drug candidates in aquatic animal tumor models, conduct mechanism studies, elucidate the molecular mechanisms of drug action, and gain insight into how drugs affect tumor cells and the surrounding microenvironment.


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