CR1
Complement receptor type 1 (CR1), also known as CD35, is encoded by the CR1 gene and has a ~200 kDa molecular weight. The extracellular domain of the most common form of CR1 is made up of several 30 repeating units called short consensus repeats (SCRs). The SCRs are distributed in four long homologous repeats (LHRs A, B, C, and D), which is result from a seven-SCR unit. CR1 is mainly in neutrophils, monocytes, erythrocytes, B and T cells, and dendritic cells as well as in microglia, neurons, and the choroid plexus of the brain, in the membrane or insoluble form. The soluble CR1 (sCR1) form is derived from proteolytic cleavage in terminal secretory vesicles or the cell membrane.
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