CR3
CR3 (complement receptor 3) is a heterodimeric protein consisting of α (CD11b) and β (CD18) transmembrane glycoproteins. CD11b is unique for CR3, while CD18 is shared by members of the β2 integrin family including LFA1, CR4, and αdβ2. CR3 is found on monocytes, macrophages, dendritic cells, neutrophils, eosinophils, NK cells, and on some T and B cells. It plays a key role in a variety of biological processes including leucocyte adhesion, activation, recruitment, host defense, phagocytosis, and immune tolerance functions through interacting with numerous ligands such as iC3b, fibrinogen, ICAM-1, ICAM-2, zymosan, factor X, haptoglobin, LPS, and oligodeoxynucleotides. For example, the binding of (1,3)-β-glucan to the lectin domain of CR3 initiates leukocytes for CR3-dependent cytotoxicity of iC3b-bound target cells. Also, CR3 is involved in FcγR-mediated phagocytic cup formation and closure.
No results for "CR3"