Characterization and Isolation of Drug Candidate
Characterization and Isolation of Drug Candidate
In the past few decades, therapeutic antibodies as drug candidates have been rapidly developed from clinical trials to the markets; they show several promising characteristics, such as excellent solubility, high specificity, and low risk. The handy and robust tool is required to monitor therapeutic antibodies in patient serum, in this case, anti-idiotypic antibodies (also known as anti-drug antibodies) which can specifically bind to the therapeutic antibodies are employed as a promising tool in the preclinical and clinical development process. It can be used as detection reagents of antibody drugs’ pharmacokinetic/pharmacodynamics (PK/PD) analysis, as well, the detection and characterization of anti-drug antibody can be a standard to evaluate the immunogenicity issues caused by antibody drugs. Besides, the high-specific anti-drug antibody can also serve as a capturing agent for antibody drugs in complex samples, as a tool for immunoaffinity enrichment even further as the reagent for purification of antibody drugs.
Anti-drug sdAb represents an ideal class of high-quality reagents suitable for therapeutic antibodies’ research. The generation of anti-drug sdAb can be a straightforward process by using our advanced phage display platform. Anti-drug sdAb which has high specificity and affinity can be used as the desired monitor for antibody drugs. Meanwhile, anti-drug sdAb has tremendous thermal and physical stability and can tolerate some strict conditions, such as possible extreme acid-base conditions or low and high-temperature conditions. Moreover, anti-drug sdAb can refold completely after denaturation to enable reusability which makes it a reliable tool for capture and purification antibody drugs.